Chemical Reaction

11/14/11 - Combes Quinoline Synthesis

     This annulation process involes the creation of a pyridine ring attached to a phenol ring.  The diaromatic ring system is created by reacting an unsubstituted aniline with a beta diketone molecule, following with a a ring closing dehydration using an acid to catilize the reaction.  This reaction is neat because it uses both the technology of turning a ketone into an amine and for the acid catalyzed ring closure.


Combes, A. Bull. Chim. Soc. France 1888, 49, 89.

Newer Post

Older Post

Paul Crichton. Powered by Blogger.

Popular Posts


I found myself blogging way too much in procrastination, so I felt it in me to create this blog to combine both my love for chemistry and my great skill of wasting time. I feel that scientific knowledge should follow along what wikipedia is producing; an open, free form for anyone to access, and I hope that this blog will bring this knowledge out to anyone who wishes to access it.

If anyone wishes to make a correction in any of my posts, or if they would like something more formally cited, please leave a message in the comments on that post and I will be more than happy to change it.