Chemical Reaction

11/14/11 - Combes Quinoline Synthesis

     This annulation process involes the creation of a pyridine ring attached to a phenol ring.  The diaromatic ring system is created by reacting an unsubstituted aniline with a beta diketone molecule, following with a a ring closing dehydration using an acid to catilize the reaction.  This reaction is neat because it uses both the technology of turning a ketone into an amine and for the acid catalyzed ring closure.

Combes

Ref:
Combes, A. Bull. Chim. Soc. France 1888, 49, 89.

Newer Post

Older Post

Paul Crichton. Powered by Blogger.

Popular Posts

About

I found myself blogging way too much in procrastination, so I felt it in me to create this blog to combine both my love for chemistry and my great skill of wasting time. I feel that scientific knowledge should follow along what wikipedia is producing; an open, free form for anyone to access, and I hope that this blog will bring this knowledge out to anyone who wishes to access it.


If anyone wishes to make a correction in any of my posts, or if they would like something more formally cited, please leave a message in the comments on that post and I will be more than happy to change it.