11/14/11 - Combes Quinoline Synthesis

     This annulation process involes the creation of a pyridine ring attached to a phenol ring.  The diaromatic ring system is created by reacting an unsubstituted aniline with a beta diketone molecule, following with a a ring closing dehydration using an acid to catilize the reaction.  This reaction is neat because it uses both the technology of turning a ketone into an amine and for the acid catalyzed ring closure.



Ref:
Combes, A. Bull. Chim. Soc. France 1888, 49, 89.