11/24/11 - Carboxylic Acid into Amide

   I figured I would continue with the carbonyl chemistry, and more specifically the carboxylic acid chemistry because it can be applied to perform so many reactions.  This is, again, a simple reaction of converting a carboxylic acid into an amide, where all that is needed is the amine (primary or secondary) or NH3 in the presence of the carboxylic acid.

RCO₂H + R'R"NH    RC(O)NR'R" + H₂O

Edit:  The addition of coupling agents in this reaction are requires, such as HATU with triethylamine and DMSO, or with T3P, triethylamine and DMF.