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Friday, December 2, 2011

12/2/11 - Creation of the Evan's Auxiliary Enolate

    This reaction works much like the selectivity within amide enolate formation, where the enolate forms in the Z formation where the R group of the enolate is eclipsed by the carbonyl.  And this reaction here causes the Evans imide to form the Z enolate selectively due to the lithium metal being an oxophilic agent to both of the carbonyls there, making sure that the bond between the N and the alpha C of the carbonyl doesn't rotate.  Now this molecule is ready to be put to use in an enolate reaction.

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